In vivo pharmacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum
نویسندگان
چکیده
منابع مشابه
In vivo pharmacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum.
A direct study evaluating whether differential drug uptake of topical 2% miconazole and 2% ketoconazole from cream formulations into human stratum corneum correlated with differential pharmacological activity against Candida albicans was investigated in healthy human subjects. A single 24-h topical dose of 2% ketoconazole cream or 2% miconazole cream was applied unoccluded, at the same dose (2....
متن کاملMechanical Properties of the Human Stratum Corneum: Hydration Effects on Graded Delamination of Human Stratum Corneum
Reinhold Dauskardt Stanford University, Professor Materials Sciences and Engineering The stratum corneum (SC) is the outermost layer of the skin. Its process of reneweal is regulated by various mechanisms, including chemical and structural gradients through the SC thickness. In this study, an in vitro mechanics approach for studying the delamination behavior of SC in the direction perpendicular...
متن کاملsynthesis of sulfides from alcohols and thiols in solvent-freeconditions and deoxygenation of sulfoxides
کاتالیست یک سنتز جدید برای تیواترها توصیف شده است. واکنش الکل ها با آریل، هتروآریل و آلکیل تیو ل ها درحضور 1،3،5- تری آزو- 2،4،6- تری فسفرین-2،2،4،4،6،6 هگزاکلراید ((tapc به عنوان یک کاتالیست موُثر، بازده های خوب تا عالی از تیواترها را حاصل می کند. علاوه براین، واکنش تحت شرایط بدون فلز و بدون حلال پیش می رود، بنابراین یک مکمل جالب برای روش های شناخته شده سنتز تیواترها ارائه می دهد. یک مکانیسم ا...
15 صفحه اولrole of cultural iran in promotion of multilaieralism in central asia and caucasus
cultural iran is a scope that is more extended than the political territories of iran as a political unit. this concept means that cultural geography(mehdi moghanlo-1383-1) of iran is greater than its political geography which, according to history, has a long history extending west-east from kandahar to the euphrates and north-south from the persian gulf to the caucasus including transoxiana a...
15 صفحه اولThe Lipid Organisation in Human Stratum Corneum and Model Systems
The primary function of the skin is to act as a barrier against unwanted influences from the environment. The barrier function of the skin is located in the superficial of the skin, the stratum corneum. The stratum corneum consists of dead cells filled with keratin and water, which are embedded in lipid regions. The lipid regions are the only continuous structure in the stratum corneum. For thi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1994
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.38.1.90